Preventive and therapeutic effects of alpha-acid glycoprotein in mice
infected with B. anthracis
Bull Exp Biol Med. 2005 Oct;140(4):439-44.
Abstract We studied the effects of alpha1-acid glycoprotein preparations on the survival rate
of BALB/c mice infected with the lethal dose of B. anthracis STI-1. Apart from native alpha1-acid
glycoprotein from donor blood, we studied 3 glycoforms differing in the affinity for concanavalin
A and structure of carbohydrate chains. The protective effect of alpha1-acid glycoprotein preparations
did not depend on its dose and was observed 3 months after treatment (0.3 mg per mouse). The protective
effect was revealed in mice receiving alpha1-acid glycoprotein preparations 2 h before infection and
24 h after inoculation of the bacterial culture. In the latter case the survival rate of animals was
much higher compared to that observed in preventive administration of alpha1-acid glycoprotein.
The protective effect practically did not depend on the time of treatment with glycoforms.
Pretreatment with alpha1-acid glycoprotein preparations significantly decreased plasma interferon-gamma
concentration. Administration of the test preparations 24 h after infection decreased the concentration
of tumor necrosis factor-alpha.
