Potapov V.D., Bakhteeva I.V., Borzenkov V.N., Titareva G.M., Wiesner J.,
Biniukov V.I.,
Ostrovskii D.N., Biketov S.F. |
|
Abstract
Antibiotic fosmidomycin will know as inhibitor of the nonmevalonate pathway of isoprenoid
biosynthesis and as possible antimalarial drug, was shown to possess a certain protective effect
on mice experimentally infected with tularemia, tiphus or coli-septicemia. Positive effect on mice
with chronic form of tuberculosis was not observed when the animals were given 1 mg of fosmidomycin
per capita twice a day. Under oxidative conditions an ESR signal of long living nitroxil free
radicals were registered in the water solution of fosmidomycin. The radicals are supposed to be
involved in the therapeutic effect of the antibiotic. |
