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Vinogradov E.V., Lindner B, Kocharova N.A., Senchenkova S.N., Shashkov A.S., Knirel Yu.A., Holst O., Gremyakova T.A., Shaikhutdinova R.Z., Anisimov A.P.

The core structure of the lipopolysaccharide from the causative agent of plague, Yersinia pestis

Carbohydrate Research. - 2002. - V. 337. - P. 775-777.

 

Abstract
The rough-type lipopolysaccharide (LPS) of the plague pathogen, Yersinia pestis, was studied after mild-acid and strong-alkaline degradations by chemical analyses, NMR spectroscopy and electrospray-ionization mass spectrometry, and the following structure of the core region was determined:

where L-α-D-Hep stands for L-glycero-α-D-manno-heptose, Sug1 for either 3-deoxy-α-D-manno-oct-2-ulosonic acid (α-Kdo) or D-glycero-α-D-talo-oct-2-ulosonic acid (α-Ko), and Sug2 for either α-D-galactose or D-glycero-α-D-manno-heptose. A minority of the LPS molecules lacks GlcNAc.


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